At NewAmsterdam Pharma, we are passionate about providing transformational therapies for patients suffering from an array of conditions where aberrant cholesterol metabolism still underlies significant morbidity and mortality. We are developing safe, convenient, oral medications for metabolic diseases to help transform the treatment paradigm for these patients.
Our lead investigational candidate, obicetrapib, is a novel, selective inhibitor that targets the Cholesteryl Ester Transfer Protein (CETP) which has been clinically shown to significantly reduce low-density lipoprotein cholesterol (LDL-C) while at the same time substantially increase high-density lipoprotein cholesterol (HDL-C).
CETP functions to transport cholesterol from ‘good’ HDL to ‘bad’ LDL. Obicetrapib works by blocking this transfer, thus substantially lowering LDL while simultaneously increasing HDL. We believe by transforming the ratio of ‘good’ versus ‘bad’ cholesterol in the body, obicetrapib holds transformative treatment potential for patients.